Coagulation-fibrinolysis abnormalities in poststroke patients.
نویسندگان
چکیده
We thank Drs Shahar, McGovern, and Spraflca for their interest in our paper in which we demonstrated, inter alia, that low doses of aspirin may not be as efficacious as higher doses. Our sample population was indeed matched, and Shahar et al are correct in pointing out that analysis for data obtained according to a matched design should have been performed. However, it is possible to ignore matching when the stratification is conditionally independent of the risk factors, given disease status. In any case, the odds ratios reported in our paper are very close to those for match-paired analysis (Table) and the x test for significance of change did not reveal any difference in statistical significance. Similar results were obtained for evaluation of risks (for the corresponding factors) computed from the estimates of logistic regression, while no potential interaction was observed. In fact, as can be seen in the Table, the conclusions remain the same regardless of the method of analysis. As for the analysis of dose effect, we indeed calculated the relative risks mentioned by Shahar et al, but considered the analysis for trend a more straightforward approach.
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ورودعنوان ژورنال:
- Stroke
دوره 25 8 شماره
صفحات -
تاریخ انتشار 1994